Erin Bumann

Associate Professor (Tenured)

Room 3144
School of Dentistry

Phone: 816-235-6450
bumanne@umkc.edu

Bumann_Erin

Erin Ealba Bumann, DDS, PhD, MS is a tenured Associate Professor in the Department of Oral and Craniofacial Sciences at the University of Missouri-Kansas City (UMKC) School of Dentistry. She received her BS in Anthropology/Zoology and DDS from the University of Michigan in 2004 and 2008, respectively. She subsequently received her PhD in Oral and Craniofacial Sciences from the University of California, San Francisco in 2013. She then conducted post-doctoral training in craniofacial biology and completed her residency and MS in Pediatric Dentistry at the University of Michigan in 2017. Dr. Bumann has been a Board-Certified Pediatric Dentist since 2018. Part of her PhD and all of her post-doctoral training were funded by a National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) K08 and Pediatric Research Loan Repayment Program. Dr. Bumann’s research has been funded by NIH/NIDCR, the Robert Wood Johnson Foundation,  the American Dental Association, and the College of Diplomates of the American Board of Pediatric Dentistry grants. She is also Fellow of the American Academy of Pediatric Dentistry and American College of Dentists.

She is a member of the:
• International Associations for Dental Research (IADR),
• American Associations for Dental, Oral and Craniofacial Research (AADOCR),
• Student Competition for Advancing Dental Research and its Application (SCADA),
• American Dental Association (ADA),
• American Dental Education Association (ADEA),
• American Association of Pediatric Dentistry (AAPD),
• College of Diplomates (COD) of the American Board of Pediatric Dentistry,
• American Society for Bone and Mineral Research (ASBMR),
• American Association of Anatomists (AAA),
• Society for Craniofacial Genetics and Developmental Biology (SCGDB), and
• Society for Developmental Biology (SDB).

Nationally, she serves on the:
• Member-at-Large on the Board of Directors of AADOCR,
• National President on the Board of Directors of SCADA,
• Member of the Legislative Advisory Committee of ADEA,
• Southwestern District Member on the Council for Scientific Affairs of AAPD, and
• New Diplomate Director on the Board of Directors of COD.

At UMKC, she serves on the:
• Doctoral Faculty,
• School of Dentistry Budget Committee,
• School of Dentistry Accreditation Self-Study Committee,
• Board Member for the UMKC Women’s Council, and
• Mentors through the UMKC Avanzando and Students in Training, in Academia, Health, and Research (STAHR) Programs.

Research
Dr. Bumann’s research has identified multiple developmental mechanisms that control the size and shape of the jaw skeleton. These experiments not only reveal that neural crest mesenchyme (NCM) autonomously regulates cell cycle progression and the timing of osteogenic differentiation, but they also indicate that cell cycle and osteogenesis are inexorably linked as a developmental module in vivo as they are in vitro. This work also uncovered a novel function for bone resorption, which is to help establish species-specific jaw length; and the transplant experiments indicate that the underlying molecular mechanisms stem from the ability of NCM to control the activity of its own derivatives (i.e., osteocytes) and also that of mesoderm-derived osteoclasts. This research shows the remarkable ability of NCM to maintain spatiotemporal control over the induction, differentiation, deposition, mineralization, and the resorption of bone is what integrates the determinants of jaw length across multiple embryonic stages and is what empowers NCM with its ability to generate skeletal variation during disease and evolution.

Additionally, Dr. Bumann’s research created a novel strategy for estimating species-specific contributions in chimeras and xenografts. Specifically, they developed a simple molecular strategy to quantify species-specific contributions in chimeras and xenografts. Many tissue-engineering approaches for repair and regeneration involve transplants between species. Yet a challenge was to distinguish donor versus host effects on gene expression. Species-specific primers were designed for reverse transcription quantitative real-time PCR (RT-qPCR) by identifying silent mutations in quail, duck, chicken, mouse and human ribosomal protein L19. This strategy enables chimeras and/or xenografts to be screened rapidly at the molecular level.

Publications
Peer-reviewed Journal Articles
• Janice E Berry, Erin L Ealba, Glenda J Pettway, Nabanita S Datta, Erica C Swanson, Martha J Somerman, and Laurie K McCauley. JunB as a Downstream Mediator of PTHrP Actions in Cementoblasts. Journal of Bone and Mineral Research, 21(2):246-57. 2006 PMID: 16418780
• Allan D. Padbury, Jr., Tolga F. Tozum, Mario Taba, Jr., Erin L. Ealba, Brady T. West, Richard E. Burney, Paul G. Gauger, William V. Giannobile, and Laurie K. McCauley. The Impact of Primary Hyperparathyroidism on the Oral Cavity. Journal of Clinical Endocrinology and Metabolism, 91(9):3439-45. 2006 PMID: 1682282
• Roger, J. M., J. A. Javarone,  L. Ealba, M. R. Markiewicz, and A. B. Morlandt. The National Student Research Group of the AADR—an introduction. Journal of Dental Research 86 (5):388-91. 2007 PMID:17452556
Ealba, E. L. and R. A. Schneider. A simple PCR-based strategy for estimating species-specific contributions in chimeras and xengografts. Development 140, 3062-3068. 2013 PMID: 23785056
• Yu, J., A. H. Jheon,  L. Ealba, B. F. Eames, K. D. Butcher, S. S. Mak, R. Ladher, T. Alliston, and R. A. Schneider. Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Developmental Biology 385(2):380-95. 2014 PMID: 24262986
Ealba, E. L., A. H. Jheon, J. Hall, C. Curantz, K. Butcher, and R. A. Schneider. Neural crest-mediated bone resorption is a determinant of species-specific jaw length. Developmental Biology 408:151-163. 2015 PMID: 26449912
Bumann, E. E. and Frazier-Bowers, S. A. A New Cyte of Orthodontic Tooth Movement. Orthodontics and Craniofacial Research Suppl 1: 125-128. 2017. PMID: 28643925
• Allard, B.A., Wang, W., Pottorf, T.S., Mumtaz, H., Silva, L.M., Jacobs, D.T., Wang, J., Bumann, E.E., and P.V. Tran. Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis. Cell and Molecular Life Sciences 78(7):3743-3762. 2021. PMID: 33683377
• Cassidy L. McDermott, Katherine Hilton, Anne T. Park, Ursula A. Tooley, Austin L. Boroshok, Lourdes Delgado Reyes, Julia A. Leonard, Muralidhar Mupparapu, JoAnna M. Scott, Erin E. Bumann, Allyson P. Mackey. Early Life Stress is Associated with Earlier Emergence of Permanent Molars. Proceedings of the National Academy of Sciences of the United States of America 118(24):e2105304118. 2021. PMID: 34103399
Bumann EE, Hahn Leat P, Wang HH, Hufft-Martinez BM, Wang W, Tran PV. Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone. Journal of Developmental Biology. 2022 May 11;10(2):17. doi: 10.3390/jdb10020017. PMID: 35645293; PMCID: PMC9149932.
• Chandrashekar G, AlQarni S, Bumann EE, Lee Y. Collaborative deep learning model for tooth segmentation and identification using panoramic radiographs. Computers in Biology and Medicine. 2022 Sep;148:105829. doi: 10.1016/j.compbiomed.2022.105829. Epub 2022 Jul 16. PMID: 35868047.
• Houchen CJ, Castro B, Hahn Leat P, Mohammad N, Hall-Glenn F, Bumann EE. Treatment with an inhibitor of matrix metalloproteinase 9 or cathepsin K lengthens embryonic lower jaw bone. Orthod Craniofac Res. 2023 Aug;26(3):500-509. doi: 10.1111/ocr.12635. Epub 2023 Feb 1. PMID: 36680416.
Bumann, E.E.; Al-Qarni S, Chandrashekar G, Sabzian R, Bohaty B, Lee Y. A novel collaborative learning model for mixed dentition and fillings segmentation in panoramic radiographs. J Dent. 2024 Jan;140:104779. doi: 10.1016/j.jdent.2023.104779. Epub 2023 Nov 24. PMID: 38007173
• Ali Akbari Ghavimi S, Faulkner TJ, Tata RR, Hemmerla AJ, Huddleston SE, Rezaei F, Lungren ES, Zhang R, Bumann EE, Ulery BD. Hydrogen Sulfide Delivery to Enhance Bone Tissue Engineering Cell Survival. Pharmaceuticals. 2024; 17(5):585. https://doi.org/10.3390/ph17050585. PMID: 38794155
• Claire J. Houchen, Saif Ghanem, Vesa Kaartinen, Erin E. Bumann. TGF-β Signaling in Cranial Neural Crest Affects Late-Stage Mandibular Bone Resorption and Length. bioRxiv [Preprint]. 2024 May 24:2024.05.24.595783. doi: 10.1101/2024.05.24.595783. PMID: 38826301 Frontiers in Physiology – Craniofacial Biology and Dental Research. Accepted 6/19/2024.
Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/erin.ealba.1/bibliography/public/
 

Book Chapter
Bumann, E.E. and V. Kaartinen. (2018) Craniofacial Morphogenesis, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 9th Edition, Section Editor, Laurie McCauley, Wiley-Blackwell.

Reference Manual
• American Academy of Pediatric Dentistry. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2020.
• American Academy of Pediatric Dentistry. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2021.
• American Academy of Pediatric Dentistry. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2022.
• American Academy of Pediatric Dentistry. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2023.

Continuing Education Program
Bumann, E.E. (2017) Electrical Oral Burns, Practical Reviews in Pediatric Dentistry, 31(8), Coordinating Editor, Arthur Nowak, Oakstone Publishing.

Staff
Dr. Erin Ealba Bumann
(bumanne@umkc.edu)

Claire Houchen
Graduate Research Assistant
(houchenc@umkc.edu)

Portia Hahn Leat
Research Aide
(plhz72@umkc.edu)

Cassie Delich
Research Assistant
(cassandra.delich@umkc.edu)