Erin Bumann

Assistant Professor

Room 3144

School of Dentistry

Phone: 816-235-6450
bumanne@umkc.edu

Bumann_Erin

Erin Ealba Bumann, DDS, PhD, MS has been a tenure-track Assistant Professor in the Department of Oral and Craniofacial Sciences at the University of Missouri-Kansas City (UMKC) School of Dentistry since September 2017. She received her BS in Anthropology/Zoology and DDS from the University of Michigan in 2004 and 2008, respectfully. She subsequently received her PhD in Oral and Craniofacial Sciences from the University of California, San Francisco in 2013. She then conducted post-doctoral training in craniofacial biology and completed her residency and MS in Pediatric Dentistry at the University of Michigan. Dr. Bumann has been a Board-Certified Pediatric Dentist since 2018. Part of her PhD and all of her post-doctoral training were funded by a National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) K08 and Pediatric Research Loan Repayment Program. Dr. Bumann’s research is currently funded by NIH/NIDCR and College of Diplomates of the American Board of Pediatric Dentistry grants. She has also been selected for funding from the Robert Wood Johnson Foundation and American Dental Association.

She is a member of the:
• International Associations for Dental Research (IADR),
• American Associations for Dental, Oral and Craniofacial Research (AADOCR),
• American Society for Bone and Mineral Research (ASBMR),
• Student Competition for Advancing Dental Research and its Application (SCADA),
• American Association of Pediatric Dentistry (AAPD),
• American Dental Association (ADA),
• American Dental Education Association (ADEA), and
• Society for Developmental Biology (SDB).

Nationally, she serves on the:
• Early-Stage Investigator Subcommittee for ASBMR,
• Gerber Advisory Council,
• Development Committee & as the Kansas City Section Councilor for AADOCR,
• Treasurer for SCADA, and
• Southwestern District Member for the Council for Scientific Affairs of AAPD.

At UMKC, she serves on the:
• Doctoral Faculty,
• Member of the Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT),
• School of Dentistry Elections Committee,
• Board Member for the UMKC Women’s Council, and
• Mentors through the UMKC Avanzando and Students in Training, in Academia, Health, and Research (STAHR) Programs.

Research

Dr. Bumann’s research has identified multiple developmental mechanisms that control the size and shape of the jaw skeleton. These experiments not only reveal that neural crest mesenchyme (NCM) autonomously regulates cell cycle progression and the timing of osteogenic differentiation, but they also indicate that cell cycle and osteogenesis are inexorably linked as a developmental module in vivo as they are in vitro. This work also uncovered a novel function for bone resorption, which is to help establish species-specific jaw length; and the transplant experiments indicate that the underlying molecular mechanisms stem from the ability of NCM to control the activity of its own derivatives (i.e., osteocytes) and also that of mesoderm-derived osteoclasts. This research shows the remarkable ability of NCM to maintain spatiotemporal control over the induction, differentiation, deposition, mineralization, and the resorption of bone is what integrates the determinants of jaw length across multiple embryonic stages and is what empowers NCM with its ability to generate skeletal variation during disease and evolution.

Additionally, Dr. Bumann’s research created a novel strategy for estimating species-specific contributions in chimeras and xenografts. Specifically, they developed a simple molecular strategy to quantify species-specific contributions in chimeras and xenografts. Many tissue-engineering approaches for repair and regeneration involve transplants between species. Yet a challenge was to distinguish donor versus host effects on gene expression. Species-specific primers were designed for reverse transcription quantitative real-time PCR (RT-qPCR) by identifying silent mutations in quail, duck, chicken, mouse and human ribosomal protein L19. This strategy enables chimeras and/or xenografts to be screened rapidly at the molecular level.

Publications

Peer-reviewed Journal Articles
Janice E Berry, Erin L Ealba, Glenda J Pettway, Nabanita S Datta, Erica C Swanson, Martha J Somerman, and Laurie K McCauley. JunB as a Downstream Mediator of PTHrP Actions in Cementoblasts. Journal of Bone and Mineral Research, 21(2):246-57. 2006 PMID: 16418780

Allan D. Padbury, Jr., Tolga F. Tozum, Mario Taba, Jr., Erin L. Ealba, Brady T. West, Richard E. Burney, Paul G. Gauger, William V. Giannobile, and Laurie K. McCauley. The Impact of Primary Hyperparathyroidism on the Oral Cavity. Journal of Clinical Endocrinology and Metabolism, 91(9):3439-45. 2006 PMID: 1682282

Roger, J. M., J. A. Javarone, E. L. Ealba, M. R. Markiewicz, and A. B. Morlandt. The National Student Research Group of the AADR—an introduction. Journal of Dental Research 86 (5):388-91. 2007 PMID:17452556

Ealba, E. L. and R. A. Schneider. A simple PCR-based strategy for estimating species-specific contributions in chimeras and xengografts. Development 140, 3062-3068. 2013 PMID: 23785056

Yu, J., A. H. Jheon, E. L. Ealba, B. F. Eames, K. D. Butcher, S. S. Mak, R. Ladher, T. Alliston, and R. A. Schneider. Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Developmental Biology 385(2):380-95. 2014 PMID: 24262986

Ealba, E. L., A. H. Jheon, J. Hall, C. Curantz, K. Butcher, and R. A. Schneider. Neural crest-mediated bone resorption is a determinant of species-specific jaw length. Developmental Biology 408:151-163. 2015 PMID: 26449912

Bumann, E. E. and Frazier-Bowers, S. A. A New Cyte of Orthodontic Tooth Movement. Orthodontics and Craniofacial Research Suppl 1: 125-128. 2017. PMID: 28643925

Allard, B.A., Wang, W., Pottorf, T.S., Mumtaz, H., Silva, L.M., Jacobs, D.T., Wang, J., Bumann, E.E., and P.V. Tran. Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis. Cell and Molecular Life Sciences 78(7):3743-3762. 2021. PMID: 33683377

Cassidy L. McDermott, Katherine Hilton, Anne T. Park, Ursula A. Tooley, Austin L. Boroshok, Lourdes Delgado Reyes, Julia A. Leonard, Muralidhar Mupparapu, JoAnna M. Scott, Erin E. Bumann, Allyson P. Mackey. Early Life Stress is Associated with Earlier Emergence of Permanent Molars. Proceedings of the National Academy of Sciences of the United States of America 118(24):e2105304118. 2021. PMID: 34103399

Book Chapter
Bumann, E.E. and V. Kaartinen. (2018) Craniofacial Morphogenesis, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 9th Edition, Section Editor, Laurie McCauley, Wiley-Blackwell.

Reference Manual
American Academy of Pediatric Dentistry. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2020.

Continuing Education Program
Bumann, E.E. (2017) Electrical Oral Burns, Practical Reviews in Pediatric Dentistry, 31(8), Coordinating Editor, Arthur Nowak, Oakstone Publishing.

Current Funding
NIH/NIDCR R03 9/21/2021 – 8/31/2023
Erin E. Bumann, DDS, PhD, MS (PI)
Wnt5a/Ror2 Signaling in Jaw Bone Development

N. Sue Seale Pediatric Research Award 7/1/2021 – 6/30/2022
Erin E. Bumann, DDS, PhD, MS (PI)
Adverse Childhood Experiences and Tooth Eruption

Staff

Dr. Erin Ealba Bumann
(bumanne@umkc.edu)

Claire Houchen
Research Assistant
(houchenc@umkc.edu)

Portia Hahn Leat
Research Aide
(plhz72@umkc.edu)