Oral and Craniofacial Sciences Faculty

Yasuyoshi Ueki, M.D., Ph.D.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications:

 

Recent Publications (More articles at PubMed)

 

  • Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis & Rheumatol 2015, 67, 656-67
  • Yoshitaka T, Kittaka M, Ishida S, Mizuno N, Mukai T, Ueki Y.Bone marrow transplantation improves autoinflammation and Inflammatory bone loss in SH3BP2 knock-in cherubism mice. Bone 2015, 71, 201-209
  • Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger E, Ueki Y. SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss. J Bone and Miner Res 2014, 29, 2618-2635
  • Yoshitaka T, Mukai T, Kittaka M, Alford LM, Masrani S, Ishida S, Yamaguchi K, Yamada M, Mizuno N, Olsen BR, Reichenberger EJ, Ueki Y. Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Reports 2014, 8, 1752-1766
  • Mukai T, Gallant R, Ishida S, Yoshitaka T, Kittaka M, Nishida K, Fox DA, Morita Y, Ueki Y. SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model. PLoS One 2014 Aug 21;9(8):e105518
  • Yoshitaka T, Ishida S, Mukai T, Reichenberger E, Kittaka M, Ueki Y. Etanercept administration to neonatal SH3BP2 Knock-In Cherubism Mice prevents TNF-a-induced inflammation and bone loss. J Bone and Miner Res 2014, 29, 1170-1182.
  • Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La Rose J, Rottapel R. Loss of tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell 2011, 147: 1324-1339.
  • Oohashi T, Naito I, Ueki Y, Yamatsuji T, Permpoon R, Tanaka N, Naomoto Y, Ninomiya Y. Clonal overgrowth of esophageal smooth muscle cells in diffuse leiomyomatosis-Alport syndrome caused by partial deletion in COL4A5 and COL4A6 genes. Matrix Biol 2011, 30:3-8
  • Mukherjee PM, Wang CJ, Chen IP, Jafarov T, Olsen BR, Ueki Y, Reichenberger EJ. Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation and function. Am J Orthod Dentofacial Orthop 2010, 138: 140.e1-140.e11.
  • Wang CJ, Chen IP, Koczon-Jaremko B, Boskey AL, Ueki Y, Kuhn L, Reichenberger E. Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties. Bone 2010, 46:1306-15.
  • Aliprantis AO, Ueki Y, Sulyanto R, Park A, Sigrist KS, Sharma SM, Ostrowski MC, Olsen BR, Glimcher LH. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 2008, 118: 3775-89
  • Ueki Y, Lin CY, Senoo M, Ebihara T, Agata N, Onji M, Saheki Y, Kawai T, Mukherjee PM, Reichenberger E, Olsen BR. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "Cherubism" mice. Cell 2007, 128: 71-83.
  • Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. Acta Med Okayama 2002, 56: 25-9.
  • Nakashima T, Fukushima K, Tahara M, Sugata KI, Ogawa T, Sugata A, Gunduz M, Ueki Y, Uno Y, Nishizaki K. Random amplified polymorphic DNA analysis applied to acute otitis media caused by penicillin non-susceptible Streptococcus pneumoniae. J Infect Chemother 2001, 4: 239-42.
  • Ueki Y, Tiziani V, Santanna C, Fukai N, Maulik C, Garfinkle J, Ninomiya C, doAmaral C, Peters H, Habal M, Rhee-Morris L, Doss JB, Kreiborg S, Olsen BR, Reichenberger E. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Nat Genet 2001, 28: 125-6
  • Reichenberger E, Tiziani V, Watanabe S, Park L, Ueki Y, Santanna C, Baur ST, Shiang R, Grange DK, Beighton P, Gardner J, Hamersma H, Sellars S, Ramesar R, Lidral AC, Sommer A, Raposo Do Amaral CM, Gorlin RJ, Mulliken JB, Olsen BR. Autosomal Dominant Craniometaphyseal Dysplasia Is Caused by Mutations in the TransmembraneProtein ANK. Am J Hum Genet 2001, 68: 1321-1326
  • Kasai N, Fukushima K, Ueki Y, Prasad S, Nosakowski J, Sugata K, Sugata A, Nishizaki K, Meyer NC, Smith RJ. Genomic structures of SCN2A and SCN3A-candidate genes for deafness at the DFNA16 locus. Gene 2001, 264: 113-22.
  • Sugata K, Fukushima K, Ogawa T, Nakashima T, Sugata A, Kasai N, Gunduz M, Ueki Y, Nishizaki K. Genetic alteration of penicillin non-susceptible Streptococcus Pneumoniae observed throughout recurrence of acute otitis media detected by amplified fragment length polymorphism analysis. Acta Med Okayama2001, 55: 167-74
  • Fukushima K, Kasai N, Ueki Y (co-first author), Nishizaki K, Sugata K, Hirakawa S, Masuda A, Gunduz M, Ninomiya Y,Masuda Y, Sato M, McGuirt WT, Coucke P, Van Camp G, Smith RJ. A gene for fluctuating,             progressive autosomal dominant nonsyndromic hearing loss, DFNA16, maps to chromosome 2q23-24.3. Am J Hum Genet 1999, 65: 141-50
  • Sado Y, Kagawa M, Naito I, Ueki Y, Seki T, Momota R, Oohashi T, Ninomiya Y. Organization and expression of basement membrane collagen IV genes and their roles in human disorders. J Biochem (Tokyo) 1998, 123: 767-76
  • Ueki Y, Naito I, Oohashi T, Sugimoto M, Seki T, Yoshioka H, Sado Y, Sato H, Sawai T, Sasaki F, Matsuoka M, Fukuda S, Ninomiya Y. Topoisomerase I and II consensus sequences in a 17-kb deletion junction of the COL4A5 and COL4A6 genes and immunohistochemical analysis of esophageal leiomyomatosis associated with Alport syndrome. Am J Hum Genet 1998, 62: 253-61
  • Khaleduzzaman M, Sumiyoshi H, Ueki Y, Inoguchi K, Ninomiya Y, Yoshioka H. Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family. Genomics 1997, 45: 304-12
  • Oohashi T, Ueki Y, Sugimoto M, Ninomiya Y. Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes. J Biol Chem 1995, 270: 26863-7

Yasuyoshi Ueki, M.D., Ph.D.Associate Professor

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