Carole McArthur, M.D., Ph.D.
Salivary gland in vitro models transfected with viral genes are employed to study the mechanism of exocrine gland destruction in AIDS and autoimmune diseases such as Lupus, Sjögren's Syndrome and Rheumatoid Arthritis. The HIV-1 tat gene is a powerful transactivator of gene expression. HIV-tat transfected salivary gland cells have been developed to understand the effect of tat on cytokines, onocogenes, MMPs and on gene expression of basement membrane proteins such as collagen and Laminin involved in pathogenesis.
Dr. McArthur is also studying the mechanism by which autoantigens are processed and become immunogenic. This is carried out in salivary gland cells in vitro undergoing apoptosis induced by cytokines such as TNF-a. This includes the cellular localization of these antigenic complexes, their redistribution, and structural modification following cell death. Therapeutic drugs related to Remicade and Etanerocept are being developed and studied with an objective to understand the mechanism underlying the side effects of these drugs.
With regards to traditional medicines, several studies directed to the development of traditional therapies for TB are underway. Dr. McArthur also collaborates with the University of Western Cape in Cape Town, South Africa.
Clinically, Dr. McArthur develops and evaluates diagnostic systems for HIV and TB. She has also contributed in the area of HIV genetics. Her lab in Cameroon was selected by the global alliance for TB drug development as a potential TB drug trial site.
Faculty and students are able to participate in clinical rotations and specific research projects by arrangement with Dr. McArthur. You may contact her at firstname.lastname@example.org or 816-235-2175.
International Health Information and Faculty & Student Opportunities