Jeffrey Gorski, Ph.D
Recent Publications (More articles at PubMed)
Gorski, JP, “Regulation of proliferation and gene expression in osteoprogenitor cells, osteoblasts, and osteocytes“ in Phosphorylated Extracellular Matrix Proteins of Bone and Dentin, M. Goldberg, ed., Frontiers between Science and Clinic in Odontology Series, Bentham Science Publishers LTD (in press, 2012).
Gorski, JP, Huffman, NT, Hillman-Marti, T, Studer, D (2012). Development of a pseudo non-aqueous high pressure freezing method to improve retention and visualization of calcium and phosphorus ions prior to nucleation of mineral crystals within osteoblastic cultures. reSolutions, in press.
Xu, C, Reed, R, Gorski, JP, Wang, Y, and Walker, MP (2012). The distribution of carbonate in human enamel and its effect on structure and mechanical properties, J. Materials Sci, in press.
Dusevich, V, Xu, C, Wang, Y, Walker, MP, and Gorski, JP (2012). Identification of a new protein-containing enamel matrix layer which bridges with the dentin-enamel junction of adult human teeth, Archives of Oral and Craniofacial Sciences, epub May 19, 2012.
Midura, RJ, Midura, SB, Su, X, Gorski, JP (2011). Separation of newly formed primary bone from older compact bone reveals clear compositional differences in bone matrix, Bone 49:1365-1374.
Gorski JP, Huffman NT, Chittur S, Midura RJ, Black C, Oxford JT, Seidah NG (2011). Inhibition of SKI-1 proprotein convertase blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. J Biol Chem 286:1836-1849.
Gorski JP (2011). Biomineralization of bone: a fresh view of the roles of non-collagenous proteins. Front Biosci 17:2598-2621.
Studer, D, Hillman, T, Huffman, NT, and Gorski, JP (2011). Eliminating exposure to aqueous solvents is necessary for early detection and ultrastructural elemental analysis of sites of calcium and phosphorus enrichment in mineralizing UMR106-01 osteoblastic cultures. Cells Tissues and Organs, Epub May 30, 2011.
Midura RJ, Vasanji A, Su X, Midura SB, Gorski JP (2009). Isolation of calcospherulites from the mineralization front of bone. Cells Tissues Organs 189(1-4):75-79.
Bonewald L, Dallas SL, Gorski JP (2009). Biomineralization of bone. In: Skeletal biology. Cold Spring Harbor, New York: Cold Spring Harbor Press.
Gorski JP, Huffman NT, Cui C, Henderson EP, Midura RJ, Seidah NG (2009). Potential role of proprotein convertase SKI-1 in the mineralization of primary bone. Cells Tissues Organs 189(1-4):25-32.
Wang C, Wang Y, Huffman NT, Cui C, Yao X, Midura S, Midura RJ, Gorski JP (2009). Confocal laser raman microspectroscopy of biomineralization foci in UMR 106 osteoblastic cultures reveals temporally synchronized protein changes preceding and accompanying mineral crystal deposition. J Biol Chem 284(11):7100-7113.
Huffman NT, Keightley JA, Chaoying C, Midura RJ, Lovitch D, Veno PA, Dallas SL, Gorski JP (2007). Association of specific proteolytic processing of bone sialoprotein and bone acidic glycoprotein-75 with mineralization within biomineralization foci. J Biol Chem 282(36):26002-26013.
Midura RJ, Vasanji A, Su X, Wang A, Midura SB, Gorski JP (2007). Calcospherulites isolated from the mineralization front of bone induce the mineralization of type I collagen. Bone 41(6):1005-1016.
Midura RJ, Wang A, Lovitch D, Law D, Powell K, Gorski JP (2004). Bone acidic glycoprotein-75 delineates the extracellular sites of future bone sialoprotein accumulation and apatite nucleation in osteoblastic cultures. J. Biol. Chem. 279(24):25464-25473.
Gorski JP, Wang A, Lovitch D, Law D, Powell K, Midura RJ (2004). Extracellular bone acidic glycoprotein-75 defines condensed mesenchyme regions to be mineralized and localizes with bone sialoprotein during intramembranous bone formation. J. Biol. Chem. 279(24):25455-25463. [The previous article was cited as a "Must Read" by E. Seeman and G. J. Strewler, Clinical and Basic Research Papers - May and June 2004 Selections, IBMS BoneKEy, July 1, 2004; 1(7): 1 - 3. ]
Gorski JP, Liu FT, Artigues A, Castagna LF, Osdoby P (2002). New alternatively spliced form of galectin-3, a member of the beta-galactoside-binding animal lectin family, contains a predicted transmembrane-spanning domain and a leucine zipper motif. J. Biol. Chem. 277(21):18840-18848.
Chunlin, Q., Brunn, J.C., Jones, J., George, A., Ramachandranand, A., Gorski, J.P., and Butler, W.T. (2001). A Comparative Study of Sialic Acid-Rich Proteins in Bone and Dentin, Eur. J. Oral Sci. 109:133-141.
Gorski, J.P., Apone, S., Shaffer, K.A., Batchelder, A., Jean, W., Williams, J.A., Shacter, E., and Eyre, D.R. (2000). Hypercalcemia Induced in Rat Marrow Ablation Model Coincides with a Peak in Bone Resorption Assessed by the NTx Marker, Bone 27: 1003-110.
Srinivasan, R., Chen, B., Gorski, J.P. and George, A. (1999). Recombinant Expression and Characterization of Dentin Matrix Protein 1, Connect. Tiss. Res. 40:251-258.
Gorski, J.P. and Olsen, B.R. (1998). Mutations in Extracellular Matrix Molecules, Curr. Opin. Cell Biology 10:586-593.
Gorski, J.P. (1998). Is All Bone the Same: Distinctive Distributions and Properties of Noncollagenous Matrix Proteins in Lamellar Versus Woven Bone Imply Different Underlying Osteogenic Mechanisms, Crit. Rev. Oral Biol. and Med. 9:201-223.
Kremer, E.A., Chen, Y., Suzuki, K., Nagase, H. and Gorski, J.P. (1998). Hydroxyapatite Induces Autolytic Degradation and Inactivation of Matrix Metalloproteinases-1 and -3, J. Bone Miner. Res. 13:1890-1902.
Gorski, J.P., Kremer, E.A., Chen, Y., Ryan, S., Fullenkamp, C., Delviscio, J., Jensen, K. and McKee, M.D. (1997). Bone Acidic Glycoprotein-75 Self-Associates to Form Macromolecular Complexes In Vitro and In Vivo with the Potential to Sequester Phosphate Ions, J. Cellular Biochemistry 64:547-564.
Magnuson, S.K., Booth, R., Porter, S. and Gorski, J.P. (1997). Bilateral Tibial Marrow Ablation in Rats Induces a Rapid Hypercalcemia Arising from Extratibial Bone Resorption Inhibitable by Methylprednisolone or Deflazacort,J. Bone Miner. Res. 12:200-209.