Oral and Craniofacial Sciences Faculty

Lynda Bonewald, Ph.D

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications:

Recent Publications (More articles at PubMed)

Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J Effects of miR-335-5p in modulating osteogenic differentiation by specifically down-regulating Wnt antagonist Dkk1. J Bone Min Res 2011 PMID 21351149.

Zhang R, Lu Y, Ye L, Yuan B, Yu S, qin C, Xie Y, Gao T, Drezner MK, Bonewald LF, Feng JQ Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Min Res. 2010 PMID 21089142

Guo, D., Keightley, A., Guthrie, J., Veno, P. A., Harris, S. E. and Bonewald, L. F. Identification of osteocyte-selective proteins. PROTEOMICS, 10:3688-98 2010, PMID 20845334.

Lu Y, Yuan b, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Boenwald LF, Feng JQ The biological function of DMP1 in osteocyte maturation is mediated by its 57kDa C-terminal fragment. J.Bone Miner Res 2010 PMID 20734454.

Fu Q, Rahaman MN, Bal BS, Bonewald LF, Kuroki K, Brown RF Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications, II. Invitro and in vivo biological evaluation. J Biomed Mater Res A 2010 PMID 20540099.

Xia Q, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald, LF, Biswas SK, Lo WK, Jiang, J., Glucocorticoid Induced Autophagy in Osteocytes J. Bone Min Res. PMID 20564240

Kitase Y, Barragan L, Qing H, Kondoh S, Jiang J, Johnson M, Bonewald LF, Mechanical Induction of PGE2 in Osteocytes blocks Glucocorticoid Induced Apoptosis Through both the -Catenin and PKA Pathways. J. Bone Min Res. PMID 20578217

Kramer I, Halleux C, Keller H, Pegurri M, Gooi JH, Weber PB, Feng JQ, Bonewald LF, Kneissel M Osteocyte Wnt/beta-catenin Signaling is Required for Normal Bone Homeostasis Mol Cell Biol 30: 3071-85 2010 PMID 20404086.

Rath AL, Bonewald LF, Ling J, Jiang JX, Van Dyke MR, Nicolella DP Correlation of cell strain in single osteocytes with intracellular calcium but not intracellular nitric oxide in response to fluid flow. J.Biomech 43:1560-4 2010 PMID 20189178.

Wang L, Dormer NH, Bonewald L, Detamore MS. Osteogenic differentiation of human umbilical cord mesenchymal stromal cells in polyglycolic acid scaffolds. Tissue Eng Part A. 16:1937-1948, 2010, PMID: 20070186

Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of Connexin 43 by GSK-3(beta)catenin signaling. Mol Cell Biol 30:206-19 2009 PMID 19841066.

Atkins GJ, Weldon KJ, Wijenayaka AR, Bonewald L, Findlay DM Vitamine K promotes mineralization, osteoblast to osteocyte transition, and an anti-catabolic phenotype by (gamma) carboxylation dependent and independent mechanisms. Am. J. Physiol Cell Physiol 297: 1358-67 2009. PMID: 19675304

Amano S, Sekine K, Bonewald LF, Ohmori Y A novel osteoclast precursor cell line, 4B12, recapitulates the features of primary osteoclast differentiation and function: Enhanced transfection efficiency before and after differentiation. J Cell Physiol 221:40-53 2009 PMID 19492422.

Sittichockechaiwut A, Scutt AM, Ryan AF, Bonewald LF, Reilly GC Use of rapidly mineralizing osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds. Bone 44:822-9, 2009 PMID 19442630.

Wang L, Singh M, Bonewald LF, Detamore MS Signalling strategies for osteogenic differentiation of human umbilical cord mesenchymal stromal cells for 3D bone tissue engineering. J Tissue Eng Regen Med 33:398-404, 2009 PMID 19434662.

Henriksen K, Neutzsky-Wulff AV, Bonewald LF, Karsdal MA Local communication on and within bone controls bone remodeling. Bone 44:1026-44, 2009. PMID 19345750.

Nicolella DP, Feng JQ, Moravits DE, Bonivitch AR, Wang Y, Dusevich V, Yao W, Lane, N, Bonewald LF Effects of nanomechanical bone tissue properties on bone tissue strain:implications for osteocyte mechanotransduction. JMNI 8: 330-1, 2008 PMID 19147962.

Farrow EG, Davis SI, Ward LM, Summers, LF, Bubbear JS, Keen R, Stamp TC, Baker LR, Bonewald LF, White KE Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. Bone 44:287-94, 2008 PMID 19007919.

Yang W, Harris MA, Heinrich JG, Guo D, Bonewald LF, Harris SE Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. Bone 44:32-45, 2008 PMID 18973839.

Barragan-Adjemian C, Lausten L, Ang DB, Johnson M, Katz J, Bonewald LF (2009). Bisphosphonate-related osteonecrosis of the jaw: model and diagnosis with cone beam computerized tomography. Cells Tissues Organs 189(1-4):284-288.

Bonewald LF, Krebsbach PH (2009). Cells tissues organs. Introduction. Cells Tissues Organs 189(1-4):5.

Dallas SL, Veno PA, Rosser JL, Barragan-Adjemian C, Rowe DW, Kalajzic I, Bonewald LF (2009). Time lapse imaging techniques for comparison of mineralization dynamics in primary murine osteoblasts and the late osteoblast/early osteocyte-like cell line MLO-A5. Cells Tissues Organs 189(1-4):6-11.

Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ (2009). Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs 189(1-4):175-185. Pmc2667139.

Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, Bonewald L, Butler WT, Feng JQ, Qin C (2009). Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells. Cells Tissues Organs 189(1-4):186-191. Pmc2727859.

Peng T, Huang B, Sun Y, Lu Y, Bonewald L, Chen S, Butler WT, Feng JQ, D'Souza RN, Qin C (2009). Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs 189(1-4):192-197. Pmc2666981.

Atkins GJ, Welldon KJ, Wijenayaka AR, Bonewald L, Findlay DM (2009). Vitamin K promotes mineralization, osteoblast to osteocyte transition and an anti-catabolic phenotype by {gamma}-carboxylation dependent and independent mechanisms. Am J Physiol Cell Physiol.

Farrow EG, Davis SI, Ward LM, Summers LJ, Bubbear JS, Keen R, Stamp TC, Baker LR, Bonewald LF, White KE (2009). Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. Bone 44(2):287-294.

Yang W, Harris MA, Heinrich JG, Guo D, Bonewald LF, Harris SE (2009). Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. J Dent Res 44(1):32-45.

Wang L, Singh M, Bonewald LF, Detamore MS (2009). Signalling strategies for osteogenic differentiation of human umbilical cord mesenchymal stromal cells for 3D bone tissue engineering. J Tissue Eng Regen Med 3(5):398-404.

Henriksen K, Neutzsky-Wulff AV, Bonewald LF, Karsdal MA (2009). Local communication on and within bone controls bone remodeling. Bone 44(6):1026-1033.

Sittichockechaiwut A, Scutt AM, Ryan AJ, Bonewald LF, Reilly GC (2009). Use of rapidly mineralising osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds. Bone 44(5):822-829.

Amano S, Sekine K, Bonewald LF, Ohmori Y (2009). A novel osteoclast precursor cell line, 4B12, recapitulates the features of primary osteoclast differentiation and function: enhanced transfection efficiency before and after differentiation. J Cell Physiol 221(1):40-53.

Nicolella DP, Feng JQ, Moravits DE, Bonivitch AR, Wang Y, Dusecich V, Yao W, Lane N, Bonewald LF (2008). Effects of nanomechanical bone tissue properties on bone tissue strain: implications for osteocyte mechanotransduction. J Musculoskelet Neuronal Interact 8(4):330-331.

Ye L, Zhang S, Ke H, Bonewald LF, Feng JQ (2008). Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets. J Dent Res 87(7):624-629.

Kuner T, Li Y, Gee KR, Bonewald LF, Augustine GJ (2008). Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. Proc Natl Acad Sci U S A 105(1):347-352. PMC2224215.

Feng JQ, Scott G, Guo D, Jiang B, Harris M, Ward T, Ray M, Bonewald LF, Harris SE, Mishina Y (2008). Generation of a conditional null allele for Dmp1 in mouse. Genesis 46(2):87-91.

Rios HF, Ma D, Xie Y, Giannobile WV, Bonewald LF, Conway SJ, Feng JQ (2008). Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. J Periodontol 79(8):1480-1490.

Bonewald LF, Johnson ML (2008). Osteocytes, mechanosensing and Wnt signaling. Bone 42(4):606-615. PMC2349095, NIHMS44963.

Siller-Jackson AJ, Burra S, Gu S, Xia X, Bonewald LF, Sprague E, Sprague E, Jiang J (2008). Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem (Epub 31 Jul 2008).

Bonewald LF (2007). Osteocytes as dynamic multifunctional cells. Ann N Y Acad Sci 1116:281-290.

Bonewald LF (2007). Osteocyte messages from a bony tomb. Cell Metab 5(6):410-411.

Kono SJ, Oshima Y, Hoshi K, Bonewald LF, Oda H, Nakamura K, Kawaguchi H, Tanaka S (2007). Erk pathways negatively regulate matrix mineralization. Bone 40(1):68-74.

Xu X, Chen Z, Wang Y, Bonewald L, Steffensen B (2007). Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions. Biochem J 406(1):147-155. PMC1948992.

Lu Y, Xie Y, Zhang S, Dusevich V, Bonewald LF, Feng JQ (2007). DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res 86(4):320-325.

Bonivtch AR, Bonewald LF, Nicolella DP (2007). Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis. J Biomech 40(10):2199-2206. PMC2094105, NIHMS16595.

Bonewald L (2006). Osteocytes as multifunctional cells. J Musculoskelet Neuronal Interact 6(4):331-333. PMC1796957, NIHMS16607.

Xiao Z, Zhang S, Mahlios J, Zhou G, Magenheimer BS, Guo D, Dallas SL, Maser R, Calvet JP, Bonewald L, Quarles LD (2006). Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression. J Biol Chem 281(41):30884-30895. PMC1797154, NIHMS16619.

Bonewald LF (2006). Mechanosensation and transduction in osteocytes. Bonekey Osteovision 3(10):7-15. PMC1847717, NIHMS16612.

Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE (2006). Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 38(11):1310-1315. PMC1839871, NIHMS16600.

Barragan-Adjemian C, Nicolella D, Dusevich V, Dallas MR, Eick JD, Bonewald LF (2006). Mechanism by which MLO-A5 late osteoblasts/early osteocytes mineralize in culture: similarities with mineralization of lamellar bone. Calcif Tissue Int 79(5):340-353. PMC1802097, NIHMS16613.

Lane NE, Yao W, Balooch M, Nalla RK, Balooch G, Habelitz S, Kinney JH, Bonewald LF (2006). Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res 21(3):466-476. PMC1797152, NIHMS16608.

Zhang K, Barragan-Adjemian C, Ye L, Kotha S, Dallas M, Lu Y, Zhao S, Harris M, Harris SE, Feng JQ, Bonewald LF (2006). E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. Mol Cell Biol 26(12):4539-4552. PMC1489126.

Bonewald LF (2005). Summary--osteocytes and mechanotransduction. J Musculoskelet Neuronal Interact 5(4):333-334.

Rios HF, Ye L, Dusevich V, Eick D, Bonewald LF, Feng JQ (2005). DMP1 is essential for osteocyte formation and function. J Musculoskelet Neuronal Interact 5(4):325-327.

Bonewald LF (2005). Generation and function of osteocyte dendritic processes. J Musculoskelet Neuronal Interact 5(4):321-324.

Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris SE (2005). Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J Biol Chem 280(21):20680-20690.

Cherian PP, Siller-Jackson AJ, Gu S, Wang X, Bonewald LF, Sprague E, Jiang JX (2005). Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell 16(7):3100-3106. PMC1165395.

Nicolella DP, Bonewald LF, Moravits DE, Lankford J (2005). Measurement of microstructural strain in cortical bone. Eur J Morphol 42(1-2):23-29. PMC1866262, NIHMS16611.

Ye L, Mishina Y, Chen D, Huang H, Dallas SL, Dallas MR, Sivakumar P, Kunieda T, Tsutsui TW, Boskey A, Bonewald LF, Feng JQ (2005). Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem 280(7):6197-6203.

Dallas SL, Zhao S, Cramer SD, Chen Z, Peehl DM, Bonewald LF (2005). Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen. J Cell Physiol 202(2):361-370.

Bonewald LF (2004). Osteocyte biology: its implications for osteoporosis. J Musculoskelet Neuronal Interact 4(1):101-104.

Karsdal MA, Andersen TA, Bonewald LF, Christiansen C (2004). Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability. DNA Cell Biol 23(3):155-165.

Yang W, Kalajzic I, Lu Y, Guo D, Harris MA, Gluhak-Heinrich J, Bonewald LF, Feng JQ, Rowe DW, Harris SE (2004). In vitro and in vivo study on osteocyte-specific mechanical signaling pathways. J Musculoskelet Neuronal Interact 4(4):386-387.

Cherian PP, Cheng B, Gu S, Sprague E, Bonewald LF, Jiang JX (2003). Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. J Biol Chem 278(44):43146-43156.

Feng JQ, Huang H, Lu Y, Ye L, Xie Y, Tsutsui TW, Kunieda T, Castranio T, Scott G, Bonewald LF, Mishina Y (2003). The dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res 82(10):776-780.

Gluhak-Heinrich J, Ye L, Bonewald LF, Feng JQ, MacDougall M, Harris SE, Pavlin D (2003). Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. J Bone Miner Res 18(5):807-817.

Ahuja SS, Zhao S, Bellido T, Plotkin LI, Jimenez F, Bonewald LF (2003). CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4. Endocrinology 144(5):1761-1769.

Bonewald LF, Harris SE, Rosser J, Dallas MR, Dallas SL, Camacho NP, Boyan B, Boskey A (2003). von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation. Calcif Tissue Int 72(5):537-547.

Lohmann CH, Schwartz Z, Liu Y, Li Z, Simon BJ, Sylvia VL, Dean DD, Bonewald LF, Donahue HJ, Boyan BD (2003). Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells. J Orthop Res 21(2):326-334.

Bonewald LF (2003). Osteocyte biology: its implications for osteoporosis. Curr Opin Orthop 14(5):311-316.

Bonewald LF (2003). Quality standards and comparative syntheses. In: Methods of organic chemistry: synthesis of peptides and peptidomimetics. Goodman M, editor. Houben-Weyl, pp. 766-772.

Zhao S, Zhang YK, Harris S, Ahuja SS, Bonewald LF (2002). MLO-Y4 osteocyte-like cells support osteoclast formation and activation. J Bone Miner Res 17(11):2068-2079.

Boyan BD, Bonewald LF, Sylvia VL, Nemere I, Larsson D, Norman AW, Rosser J, Dean DD, Schwartz Z (2002). Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblasts. Steroids 67(3-4):235-246.

Bonewald L (2007). Diagnostic methods for the detection of congenital bone defects. US Patent No. pending patent. (August 17, 2007).

Bonewald LF, Mundy GR, Gallwitz WE (2002). Suppression, by 5-Lipoxygenase inhibitors, of bone resorption. U.S. Patent No. 6,455,541. (September 24, 2002).

Ahuja SA, Bonewald LF (2002). Methods of reducing bone loss with CD40 ligand. U.S. Patent No. 6,482,411. (November 19, 2002 ).

Bonewald LF, Kato Y (2002). Osteocyte cell lines. U.S. Patent No. 6,358,737. (March 19, 2002).

Ahuja SS, Bonewald LF (2001). CD40 agonist compositions and methods of use. European Patent No. WO0116180.

Lynda Bonewald, Ph.D
UMKC Vice Chancellor for Translational and Clinical Research

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Mineralized Tissue Biology
UMKC-CEMT