Bone Repair and Military Readiness
Investigators: J David Eick (PI), Lynda F Bonewald (Co-PI), Yong Wang (Co-I), UMKC-Dentistry; Kathleen Kilway (Co-I), UMKC-Chemistry
While an increasing proportion of soldiers are surviving their battlefield injuries due to protective body armor, limb injuries are increasing. Projectiles from explosive devices cause complex damage to extremities such as open fractures with varying degrees of bone loss. Skeletal instability puts the surrounding soft-tissue at risk for additional injury. Early battlefield stabilization has direct benefit not only to the skeleton, but to traumatized soft-tissue and may have beneficial systemic effects. The method of choice for stabilization of bone fracture and injuries has been external fixation and splinting devices or the use of bone cements. However, these devices are not recommended for weight-bearing with unstable fractures. To begin to address this problem, we propose to examine the use of silorane resin systems for the delivery of bone materials to temporarily stabilize bone injuries until the injured soldier can be safely transported to a medical center for permanent intervention and treatment.