Bone Fracture Repair in Animals Using a New Bone Cement
Investigators: J David Eick (PI), Lynda F Bonewald (Co-PI), Yong Wang (Co-I), UMKC-Dentistry; Kathleen Kilway (Co-I), UMKC-Chemistry; Thomas Schuman (Co-I), MS&T-Chemistry
Pets and large animals such as horses now benefit from biomaterials used to hold and heal bone fractures. Frequently, bone cement is used to stabilize fractures and prosthetic devices such as those used for hip replacement in dogs with hip dysplasias. The currently used bone cement is polymethylmethacrylate (PMMA) in veterinary practice. Although PMMA is a very strong resin, it has several drawbacks such as preventing the healing of the bone due to severe toxicity and heat generation and it shrinks and contracts when it solidifies. We have developed silorane-based resins superior to PMMA in many characteristics such as much less shrinkage without an associated proportional reduction in strength. Siloranes are less toxic and less heat generating and our results suggest support of bone formation. We will develop composites with enhanced strength and biocompatibility. Fillers will be included in the form of hollow microspheres or biocompatible, biodegradable glass that could be used to contain and act as carriers for antibiotics or growth factors that induce bone growth and blood vessel formation.